One treatment – Many pain sources
Amidst the ever expanding array of treatments CBDs can provide, traditional pain management is one of the earliest. By understanding how pain signals interact with our bodies we can better understand how cannabidiol helps to prevent the transmitting of those signals. Thus, providing a sufferer with relief from pain from a variety of antagonists. Not only masking the pain, CBDs actually work to correct the source of the problem.
For thousands of years, ancient cultures use CBD rich hemp oil topically to heal skin lesions and serve as a topical anesthetic. Other ancient societies report using the oil and extract to cure headaches. Regardless of the pain source, CBD laden products provide thorough relief. For the past 40 years, research into exactly how secondary cannabinoids like CBD acts as analgesics yields bountiful proof of work of cannabis’ effective treatment of pain. Due to the versatile nature of cannabidiol, CBD administration works to relieve pain in a surprisingly vast amount of ways.
The Human Pain Pathway
Throughout our body, in a tangled web of nerves are receptors ready to transmit their message back to the brain. Pain receptors, called nociceptors will activate by an event, sending an electrical current down the periphery nerve to back to the spinal cord. Here, the pain message travels up the spinal cord for sorting at the brain stem. The message of pain is received by the thalamus region of the brain. The thalamus then sends the signal to a variety of regions in our brain. Each region has a job: sense the pain, dislike the pain, and learn from our displeasure in the pain. Damaged or inflamed nerves will continually send signals of pain so long as there is nociceptor agitation. Analgesics work to combat the reception of these continued pain messages.
Cancerous Tumor Pain
Anandamide Deactivation Inhibition
In clinical studies, CBD administration for pain management of tumor inflicted mice effectively increased the pain threshold of the tumor sufferor. Research links diminishing anandamide levels at the tumour site to pain in cancer patients. CBD is known for its ability to increase anandamide levels through anandamide deactivation inhibition. When endocannabinoid levels return to normal at the tumor site, the tolerance for pain increases. CBDs interplay with anandamide is also proving to be an extremely effective antipsychotic for schizophrenia sufferers.
For combating inflammation, the result of which is nociceptor agitation, CBD is know to induce apoptosis of the damaged cells. When a damaged cells is fated with a premature death, it dies by necrosis. In necrosis, dying cells leak their components to the tissues and receptors surrounding it which leads to inflammation and calls for some form of pain management. Cell death by apoptosis is considered programmed: the death is natural, when the cell is no longer functional, the chemical imbalance rendering it useless triggers the death. When a cell that dies naturally does so without causing inflammation and pain. CBDs act as catalysts at the cell level to alter the nature of a damaged cell’s decay. Thus converting a death by necrosis to death by apoptosis. Ongoing research also finds that inducing apoptosis by cannabinoids is also an effective cancer combative.
Clinical Endocannabinoid Deficiency
CBD is becoming increasingly famous for its efficacy in treatment of neuropathic pain like fibromyalgia. At its core, fibromyalgia is excessive nerve sensitivity resulting in ongoing pain signals. Recent studies have show that a condition called Clinical Endocannabinoid Deficiency results in a number of chronic, painful conditions like fibromyalgia. High doses of cannabinoid CBD eliminates the deficiency within the body down to the cell level. This the deficiency cured, the body returns to stasis and the cells no longer need to send excessive signals as a cry for help Thousands of CBD users are coming forward now with their successes that just about every fibromyalgia resource now has information on CBDs as treatment. CED is also believed to be an underlying cause of migraines and IBS – both of which are alleviated by CBD.